Your have 310 markup validation errors. That's a lot, so be sure to find out what's causing them and get them taken care of.
On to my review.
The site made a very good first impression on me. The layout is clean, simply, and to-the-point. The rollover effects on the menus are excellent. The color scheme is good. The layout doesn't distract me from the content. You actually HAVE content.
One thing that kind of bothers me is that there is no real easy way to determine what page I'm on once I'm there. For example, when I go to Politics -> Political Opinion, there is no title or any indication that I am on the Political Opinion page. Your menu system is well done in my opinion, but your visitors will still get lost/confused without some sort of indication of what page they are on.
My recommendation for this would be to utilize the space under your main menu bar (the space where the submenu pops up). Place the page title there (or even better: a breadcrumb trail), and your site will seem 10x as organized. When visitors go to a different page, you can simply let the submenu popup over the title.
Another thing I noticed was that it was a bit difficult to choose submenu options for your Science, Entertainment, Gaming, and Sports. I have to move my mouse over the item, then carefully move it down, then carefully move it over to the desired link way on the left. What if you had the left edge of each submenu aligned with the left edge of the button that generates it? This would not only look better (in my opinion), but would also make it FAR easier for visitors to navigate.
Lastly, The sidebar thing on the right side of your pages seems too far towards the center of the page. I'd try decreasing the margin to the right of that sidebar to the size of its top margin. It will look much more consistent.
Overall, I really like this site. Nice use of CSS, too. I can tell a lot of time was put into the design. Nicely done.
The Beer Monocle. Classy.